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KMID : 0043320230460090723
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Archives of Pharmacal Research
2023 Volume.46 No. 9 p.723 ~ p.743
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Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs
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Surapriya Surendranath Prabhu
Aathira Sujathan Nair
Saiprabha Vijayakumar Nirmala
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Abstract
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The fact that mitochondria play a crucial part in energy generation has led to the nickname “powerhouses” of the cell being applied to them. They also play a significant role in many other cellular functions, including calcium signalling, apoptosis, and the creation of vital biomolecules. As a result, cellular function and health as a whole can be significantly impacted by mitochondrial malfunction. Indeed, malignancies frequently have increased levels of mitochondrial biogenesis and quality control. Adverse selection exists for harmful mitochondrial genome mutations, even though certain malignancies include modifications in the nuclear-encoded tricarboxylic acid cycle enzymes that generate carcinogenic metabolites. Since rare human cancers with mutated mitochondrial genomes are often benign, removing mitochondrial DNA reduces carcinogenesis. Therefore, targeting mitochondria offers therapeutic options since they serve several functions and are crucial to developing malignant tumors. Here, we discuss the various steps involved in the mechanism of cancer for which mitochondria plays a significant role, as well as the role of mitochondria in diseases other than cancer. It is crucial to understand mitochondrial malfunction to target these organelles for therapeutic reasons. This highlights the significance of investigating mitochondrial dysfunction in cancer and other disease research.
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KEYWORD
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Mitochondrial dysfunction, Oncogenic signaling, Genome mutations, Apoptosis, Carcinogenesis
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